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✪ Usability, Acceptability, and Barriers to Implementation of a Collaborative Agenda-Setting Intervention (CASI) to Promote Person-Centered Ovarian Cancer Care: Development Study

Authors:

Rachel A Pozzar, James A Tulsky, Donna L Berry, Jeidy Batista, Paige Barwick, Charlotta J Lindvall, Patricia C Dykes, Michael Manni, Ursula A Matulonis, Nadine J McCleary, and Alexi A Wright

University of Washington affiliated authors are displayed in bold.

✪ Open Access

Published: March 2025

Read the full text in the open access journal JMIR Cancer

Abstract:

Background

People with advanced ovarian cancer and their caregivers report unmet supportive care needs. We developed a Collaborative Agenda-Setting Intervention (CASI) to elicit patients’ and caregivers’ needs through the patient portal before a clinic visit and to communicate these needs to clinicians using the electronic health record.

Objective

We aimed to assess the usability and acceptability of the CASI and identify barriers to and facilitators of its implementation.

Methods

We recruited English- and Spanish-speaking patients, caregivers, and clinicians from the gynecologic oncology program at a comprehensive cancer center. Participants used the CASI prototype and then completed individual cognitive interviews and surveys. We assessed usability with the System Usability Scale (scores range 0‐100, scores ≥70 indicate acceptable usability) and acceptability with the Acceptability of Intervention Measure and Intervention Appropriateness Measure (scores for both measures range from 1 to 5, higher scores indicate greater acceptability). Interviews were audio recorded, transcribed, and analyzed using directed content analysis. Domains and constructs from the Consolidated Framework for Implementation Research comprised the initial codebook. We analyzed survey data using descriptive statistics and compared usability and acceptability scores across patients, caregivers, and clinicians using analyses of variance.

Results

We enrolled 15 participants (5 patients, 5 caregivers, and 5 clinicians). The mean System Usability Scale score was 72 (SD 16). The mean Acceptability of Intervention Measure and Intervention Appropriateness Measure scores were 3.9 (SD 1.0) and 4.1 (SD 0.8), respectively. Participants viewed the CASI content and format positively overall. Several participants appreciated the CASI’s integration into the clinical workflow and its potential to increase attention to psychosocial concerns. Suggestions to refine the CASI included removing redundant items, simplifying item language, and adding options to request a conversation or opt out of supportive care referrals. Key barriers to implementing the CASI include its complexity and limited resources available to address patients’ and caregivers’ needs.

Conclusions

The CASI is usable and acceptable to patients with advanced ovarian cancer, caregivers, and clinicians. We identified several barriers to and facilitators of implementing the CASI. In future research, we will apply these insights to a pilot randomized controlled trial to assess the feasibility of comparing the CASI to usual care in a parallel group-randomized efficacy trial.

**This abstract is posted with permission under the Creative Commons Attribution 4.0 International License**

Perspectives on Implementing a Communication Facilitator Intervention From a Critical Care Setting

Authors:

Jennifer Im, Erin Blakeney, Danae Dotolo, Anna Ungar, Rebecca Barton, Bryan J Weiner, Kathryn I Pollak, Elizabeth Nielsen, Lisa Hudson, Nancy Kentish-Barnes, Claire Creutzfeldt, Ruth A Engelberg, J Randall Curtis

University of Washington affiliated authors are displayed in bold.

Subscription Required for Full Text Access

Published: February 2025

Read the full text in the subscription access Journal of Pain and Symptom Management

✪ Usability of a cross-system housing stability program for juvenile courts: A multimethod study of probation counselor perspectives

Authors:

Asia S. Bishop, Sarah C. Walker, Ella B. Baumgarten, Kristin Vick, & Taquesha Dean

University of Washington affiliated authors are displayed in bold.

✪ Open Access

Published: February 2025

Read the full text in the open access journal Implementation Research and Practice

Abstract:

Background

Youth in contact with the juvenile legal system experience disproportionate rates of homelessness. While system contact is a critical intervening point, juvenile courts do not typically offer housing services. One solution is to refer youth to evidence-based, community-based services to meet housing-related needs, but a myriad of individual and organizational factors often impede court staff from making such referrals. Housing Stability for Youth in Courts (HSYNC) is a novel, cross-system service linkage model for court-involved youth facing housing instability. HSYNC was developed using codesign as a strategy to improve usability and incorporated evidence on juvenile court linkage strategies effective at increasing service referrals and improving outcomes.

Method

The current study utilized a multimethod approach to evaluate the usability of HSYNC from the perspective of juvenile probation counselors (JPCs) as one group of end-users. As part of the pilot implementation study, survey (N = 15) and semi-structured interview (N = 20) data were obtained from JPCs from four juvenile courts in one northwestern state.

Results

Survey results indicated good usability for HSYNC (mean implementation strategy usability scale score of 80). Themes from the interviews complemented survey findings, pointing to HSYNC as a value-added program that integrated well with existing probation practices. The housing navigator's approach was highlighted as a strong facilitator of program usability. Themes also provided greater insight into implementation barriers (i.e., individual and contextual factors) and areas for improvement (e.g., eligibility screening process).

Conclusions

Drivers of program usability and implications for program improvement to address identified implementation challenges to ensure the HSYNC model is effective and sustainable long-term are discussed.

Plain Language Summary

A study examining the key factors impacting successful implementation of a novel housing stability program to address homelessness risk for court-involved youth and their families.
Court-involved youth experience disproportionate rates of homelessness, yet housing services are not traditionally offered by juvenile courts. Court staff, such as probation staff, can refer youth to community-based services to meet their housing needs. Unfortunately, many factors complicate whether these referrals are made, including staff feeling overburdened by other work obligations and uncertainty about whether referring youth to community services fits within their job responsibilities. In this study, we surveyed and interviewed probation staff who were responsible for implementing a new referral-based housing stability program—Housing Stability for Youth in Courts (HSYNC)—to understand whether the program addressed previously identified barriers to referral-making. A unique feature of HSYNC is that there is a dedicated housing navigator, who works as a “linkage specialist” to support probation staff in making referrals while working directly with youth and families to access housing-related services in the community. Our findings suggest that, from the perspective of probation staff, HSYNC is considered to be a user-friendly program that is well-aligned with existing court practices. The housing navigator and their unique approach to working with probation staff, youth, and families was perceived as the strongest facilitator of implementation success; meanwhile, screening for program eligibility was the biggest barrier, pointing to the need for improvement before HSYNC is widely implemented. The persistent intersection of youth housing instability and court involvement calls for better coordination between juvenile courts and community agencies providing housing-related services. From the probation perspective, HSYNC offers a viable solution to meeting youths’ housing needs without creating additional workload burden for court staff.

**This abstract is posted with permission under the Creative Commons Attribution 4.0 International License**

The difference-making role of staff support in implementing nurse care management for opioid use disorder treatment: A configurational analysis

Authors:

Theresa E Matson, Amy K Lee, Edward J Miech, Paige D Wartko, Rebecca C Phillps, Mary Shea, Andrea Altschuler, Aimee N C Campbell, Colleen T Labelle, Julia H Arnsten, Jordan M Braciszewski, Joseph E Glass, Viviana E Horigian, Mark T Murphy, Mohammad Zare-Mehrjerdi, and Katharine A Bradley

University of Washington affiliated authors are displayed in bold.

Subscription Required for Full Text Access

Published: February 2025

Read the full text in the subscription access Journal of Substance Use and Addiction Treatment

✪ Health Care Professional Adherence to Breast Cancer Management Guidelines in Nigeria

Authors:

Anya Romanoff, Olalekan Olasehinde, Kathleen Lynch, Sharif Folorunso, Oluwatosin Omoyiola, Betiku Omolade, Adeleye Omisore, Chukwuma Eze Okereke, Olayide Agodirin, Abubakar Bala Muhammad, Nuhu Ali, Omorodion Irowa, Nneka Sunday Nweke, Uchechukwu Emmanuel Nwokwu, Adewale Aderounmu, Funmilola Wuraola, Hannah L Kalvin, Rivka Kahn, Grace Fitzgerald, Cristina Olcese, Alexia Iasonos, Victoria L Mango, Jamie S Ostroff, Rachel Vreeman, Benjamin O Anderson, T Peter Kingha, and Olusegun Isaac Alatise

University of Washington affiliated authors are displayed in bold.

✪ Open Access

Published: February 2025

Read the full text in the open access journal JAMA Network Open

Abstract:

Importance

In Nigeria, 80% of breast cancer is diagnosed at an advanced stage, when clinical management is complex and necessitates multidisciplinary collaboration. The Nigerian Federal Ministry of Health promotes multidisciplinary tumor board (MDT) discussions and endorses the National Comprehensive Cancer Network Harmonized Guidelines for Sub-Saharan Africa (Harmonized Guidelines) to standardize breast cancer care, but the extent of their clinical utilization is not well understood.

Objective

To identify barriers to and facilitators of the standardization of breast cancer care in Nigeria as reflected by awareness and consultation of resource-adapted guidelines.

Design, Setting, and Participants

For this survey study, health care professionals (HCPs) involved in breast cancer care in Nigeria were recruited electronically through medical societies and snowball sampling from November 1, 2023, to January 31, 2024.

Exposure

Breast cancer care guidelines.

Main Outcomes and Measures

Current breast cancer guideline awareness, adherence among specialties, and multidisciplinary management in Nigeria were evaluated. A multinational, multidisciplinary team developed and distributed an HCP questionnaire. Cochran-Armitage trend tests and logistic regression assessed associations with guideline awareness and use.

Results

A total of 277 HCPs (median [IQR] age, 42 [38-48] years; 211 of 275 [77%] male), including 124 surgeons (45%), 59 radiologists (21%), 49 clinical oncologists (18%), and 45 pathologists (16%), responded to the survey. Of 274 HCPs, 253 (92%) believed that breast cancer guidelines contribute to better patient outcomes, and 100 of 195 (51%) routinely consulted guidelines. Of 273 HCPs, 103 (38%) had regular engagement in breast cancer MDT discussions. Only 93 of 277 HCPs (34%) were aware of resource-adapted Harmonized Guidelines; both guideline awareness and consultation increased with the frequency of MDT participation. Completing a cancer-related fellowship (OR, 14.56; 95% CI, 6.24-40.00; P < .001), clinical oncology specialization (OR vs surgery, 0.20 [95% CI, 0.09-0.42]; OR vs pathology, 0.05 [95% CI, 0.02-0.14]; OR vs radiology, 0.02 [95% CI, 0.01-0.06]; P < .001), devoting more time to breast health care delivery (OR, 1.04; 95% CI, 1.02-1.05; P < .001), and regular MDT engagement (OR for weekly vs none, 5.13; 95% CI, 1.69-17.35; P = .04) were associated with consulting guidelines regularly on univariable analysis. To improve guideline adherence, 230 of 277 HCPs (83%) reported needing regular MDT discussions.

Conclusions and Relevance

In this survey of HCPs across Nigeria, half reported routinely consulting guidelines and only one-third were aware of the Harmonized Guidelines, which are resource adapted and endorsed by the Nigerian Federal Ministry of Health. Approximately one-third of HCPs reported engaging in regular breast cancer MDT discussions; guideline awareness and consultation increased as frequency of MDT participation increased. Opportunities for disseminating knowledge, such as MDT discussions and fellowship training, are essential to standardize breast cancer care delivery in Nigeria.

**This abstract is posted with permission under the Creative Commons Attribution 4.0 International License**

Feasibility of Using Patient Navigation to Improve Identification of Hereditary Cancer Syndromes in Newly Diagnosed Colorectal Cancer Patients

Authors:

Emma Sears, Jacky Dahlquist, Sarah Stayman, Cynthia Ko, Eric Q. Konnick, Allison Cole, Ying Zhang, Marlana Kohn, Vida Henderson, and Sarah Knerr

University of Washington affiliated authors are displayed in bold.

Subscription Required for Full Text Access

Published: February 2025

Read the full text in the subscription access journal Genetics in Medicine

✪ How integrated knowledge translation worked to reduce federal policy barriers to the implementation of medication abortion in Canada: a realist evaluation

Authors:

Sarah Munro, Kate Wahl, Sheila Dunn, Courtney Devane, Linda C. Li, & Wendy V. Norman

University of Washington affiliated authors are displayed in bold.

✪ Open Access

Published: February 2025

Read the full text in the open access journal Implementation Science Communications

Abstract:

Background

Initial Canadian federal regulations for the abortion pill, mifepristone, had the potential to impede safe and equitable access to this medication. To catalyze evidence-based regulatory change, we engaged health policy, health system, and health services decision makers, and health professional organizations in integrated knowledge translation (iKT), a research approach that engages the users of research as equal partners.

Methods

We conducted a realist evaluation of what iKT strategies worked, for whom, and in what context to impact federal mifepristone regulations. We constructed initial program theories (if–then statements about how iKT worked). We tested the initial program theories using interviews with researchers and knowledge partners and triangulated with analysis of research programme documents. We configured the evidence in relation to the initial program theories, and refined program theories into causal explanatory configurations.

Results

We analyzed 38 interviews with researchers, health professional leaders, advocacy group leaders, and administrative government policy makers, as well as 49 program documents. Our results indicated that researcher partnerships with stakeholders had a meaningful impact on the removal of restrictions. We found key components of the causal explanatory configurations included: researcher motivation to move evidence into action, trusted reputations as credible sources of evidence, strategic partnerships, understanding of health policy processes, and researcher roles as a trusted convenor between key groups and decision makers.

Conclusions

Our study identifies several practical and transferable approaches to impactful iKT. The findings may be of relevance to researchers focused on public health topics subject to stigma.

Contributions to the literature
  • The effect of integrated knowledge translation (iKT) on public health policy is ambiguous, especially for issues that may be stigmatized, like abortion.
  • To bridge this knowledge gap, we evaluated the iKT used to support Canadian federal drug regulatory decisions to remove restrictions for the medication abortion pill, mifepristone.
  • Our realist evaluation identified several practical and transferable approaches to impactful iKT in complex policy systems that comprise an ‘iKT mindset’.
  • Key approaches for researchers include acting on motivations to move evidence into policy, building trusted reputations as credible sources of evidence, understanding and targeting policy levers, acting as a source of strategic evidence, and acting as a trusted convenor between key groups and decision makers.
  • Our use of realist methodology contributes to theoretical and empirical understandings of iKT with policy makers and has relevance for other stigmatized topics including opioid safe supply, vaccination, and climate change.

**This abstract is posted with permission under the Creative Commons Attribution 4.0 International License**

Pilot Testing a Digital Transdiagnostic Mental Health Intervention for Use Among Immigrant and Refugee Youth in the USA: A Mixed Methods Evaluation of Clinical and Implementation Outcomes

Authors:

Katrin E. Fabian, Morgan Turner, Katherine T. Foster, Lydia Chwastiak & Bradley H. Wagenaar

University of Washington affiliated authors are displayed in bold.

Subscription Required for Full Text Access

Published: February 2025

Read the full text in the subscription access Journal of Technology in Behavioral Science

Barriers and facilitators to implementing enteral resuscitation for major burn injuries: Reflections from Nepalese care providers

Authors:

Raslina Shrestha, Kajal Mehta, Aldina Mesic, Dinasha Dahanayake, Manish Yadav, Shankar Rai, Kiran Nakarmi, Pariwesh Bista, Tam Pham, and Barclay T. Stewart

University of Washington affiliated authors are displayed in bold.

Subscription Required for Full Text Access

Published: February 2025

Read the full text in the subscription access journal Burns

✪ Healthcare provider perspectives on integrating HIV care into cancer centers in Malawi, South Africa, Uganda, and Zimbabwe

Authors:

Michalina A Montaño, Alfred Jatho, Cecilia Nassolo, Noleb Mugisha, Agatha Bula, Maganizo B Chagomerana, Margaret Borok, Takudzwa J Mtisi, Maureen Joffe, Rachel A. Bender Ignacio, and Ntokozo Ndlovu

University of Washington affiliated authors are displayed in bold.

✪ Open Access

Published: January 2025

Read the full text open access in the journal Translational Oncology

Abstract:

Background

In East and Southern Africa, treatment of people with concomitant cancer and HIV is complicated by siloed service delivery pathways, which exacerbate barriers to care and impact clinical decision-making. Integrating HIV care into cancer treatment centers may improve service delivery and overall patient outcomes.

Methods

We administered a questionnaire to clinicians and support staff at tertiary cancer referral centers in Malawi, Zimbabwe, Uganda, and South Africa to assess level of concern about clinical management of people with HIV (PWH) and cancer, barriers to integrating HIV service delivery into cancer treatment delivery, and beliefs related to HIV, antiretroviral therapy (ART), and integrated care.

Results

Of 195 clinician and support staff participants, 165 (85 %) were direct providers of cancer-associated care. Over 50 % indicated that they held concerns about survival, treatment complications, co-morbidities, and drug-drug interactions in PWH compared to patients without HIV. Over 80 % agreed that knowing cancer patients’ HIV status, ART status, and ART regimen would facilitate better care and should be considered in cancer care decision-making. Overall, respondents were optimistic that HIV-related care could be easily integrated into cancer care provision. The most-frequently endorsed barriers to integrated care were workspace limitations, disruptions to workflow, availability of staff, and cost to the hospital and to patients.

Conclusions

Cancer clinicians and support staff report overall positive attitudes toward integrating HIV and cancer service delivery. Research to elucidate service delivery pathways and contextualize system-based barriers to integrating care are critical next steps to optimize linked HIV and cancer care delivery.

**This abstract is posted with permission under the Creative Commons Attribution 4.0 International License**